Selective vulnerability in the nervous system refers to the fact that
subpopulations of neurons in different brain systems may be more or
less prone to abnormal function or de...
The oncogenic transcription factor FOXM1 is overexpressed in the
majority of human cancers, and it is a potential target for anticancer
therapy. We identified proteasome inhib...
Exogenous cytokine therapy can induce systemic toxicity, which might
be prevented by activating endogenously produced cytokines in local
cell niches. Here we developed antibod...
BACKGROUND: Results in neonatal screening programs aiming at detection
of congenital adrenal hyperplasia (CAH) can only report elevated
levels of 17-hydroxy-progesterone (17-O...
Maternal primary cytomegalovirus (CMV) infection, reactivation, or
reinfection with a different viral strain may cause fetal injury and
adverse pregnancy outcomes. Increasing ...
HIV-1 uses cellular machinery to bud from infected cells. This
cellular machinery is comprised of several multiprotein complexes
known as endosomal sorting complexes required ...
Background: Brain cancer is a group of clinically,
histopathologically and molecularly heterogeneous diseases, with
different outcomes and responses to treatment. Since the t...
One challenge in studying chronic infectious and inflammatory
disorders is understanding how host pattern recognition receptors
(PRRs), specifically toll-like receptors (TLRs)...
Thymine DNA glycosylase (TDG) is a multifunctional protein that plays
important roles in DNA repair, DNA demethylation, and transcriptional
regulation. These diverse functions...
Gastric cancer is the third leading cause of cancer-related death
worldwide. Our basic understanding of gastric cancer biology falls
behind that of many other cancer types. Cu...
Researchers are developing molecular switches that can inactivate
transplanted genes, paving the way for safer gene therapies. First
up—better treatments for cancer
-- Rea...
Salary will be commensurate on experience.: Department of Genetic
Medicine, Weill Cornell Medical College: The Department of Genetic
Medicine at Weill Cornell Medical College ...