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Non-Classical Action of Ku70 Promotes Treg Suppressive Function through a FOXP3-Dependent Mechanism in Lung Adenocarcinoma
Using a lung-colonizing tumor model of in mice with Treg-specific Ku70 deficiency, scientists demonstrated that deletion of Ku70 in Treg cells led to a stronger anti-tumor response and slower tu...
ZNF652 Exerts a Tumor Suppressor Role in Lung Cancer by Transcriptionally Downregulating Cyclin D3
Investigators identified that ZNF652 was downregulated in human lung cancer tissues and cell lines. Low ZNF652 expression was associated with poor survival in lung cancer patients.
The Role of Baseline 18F-FDG PET/CT for Survival Prognosis ...ndergoing Immunotherapy: A Systematic Review and Meta-Analysis
Researchers investigated the prognostic ability of baseline 18F-FDG PET/CT in patients with non-small-cell lung cancer (NSCLC) receiving immunotherapy.
TMEM106B Amyloid Filaments in the Biondi Bodies of Ependymal Cells
Researchers showed that Biondi bodies were strongly immunoreactive with TMEM239, an antibody specific for inclusions of transmembrane protein 106B (TMEM106B). Biondi bodies were labelled by both...
A Microglia-Containing Cerebral Organoid Model to Study Early Life Immune Challenges
Investigators characterized a model of cerebral organoids with integrated microglia. These organoids expressed typical microglial markers and responded to inflammatory stimuli.
Dormancy-Inducing 3D Engineered Matrix Uncovers Mechanosensitive and Drug-Protective FHL2-p21 Signaling Axis
Scientists explored dormancy-inducing 3D engineered matrices, which generated mechanical confinement and induced growth arrest and survival against chemotherapy in cancer cells.
Extracellular Matrix Limits Nanoparticle Diffusion and Cellular Uptake in a Tissue-Specific Manner
The authors evaluated how tissue-specific properties of the ECM affect nanoparticle diffusion using fluorescence video microscopy and cellular uptake via flow cytometry.
Recapitulating the Adenoma–Carcinoma Sequence by Selectio...c Mutations in Mismatch-Repair-Deficient Human Colon Organoids
Scientists demonstrate that long-term culture of mismatch-repair-deficient organoids allowed the selection of spontaneous oncogenic mutations through the sequential withdrawal of Wnt agonists, e...
Bio-Orthogonal Tuning of Matrix Properties During 3D Cell Culture to Induce Morphological and Phenotypic Changes
Investigators described a protocol for producing a synthetic extracellular matrix that could be modified in situ during three-dimensional cell culture.
Genomic and Transcriptomic Landscape of Human Gastrointestinal Stromal Tumors
The authors comprehensively described the genomic and transcriptomic landscape of a cohort of 117 gastrointestinal stromal tumors (GISTs) including 31 low-risk, 18 intermediate-risk, 29 high-ris...
Cancer-Associated Fibroblasts Shape Early Myeloid Cell Resp...Immunogenic Signals in Next Generation Tumor Organoid Cultures
Primary cancer-associated fibroblast-containing triple cultures successfully modelled tumor-like macrophage-like phenotypes ex vivo, allowing the assessment of their functional and phenotypic ch...